Autosomal recessive polycystic kidney disease is a truly catastrophic monogenetic disease, causing death and end stage renal disease in neonates and children.Using PCK female rats, an orthologous model of autosomal recessive polycystic kidney disease harboring mutant Pkhd1, we tested the hypothesis that intravenous renal cell transplantation with n
Real-time monitoring of rhamnose induction effect on the expression of mpt64 gene fused with pelB signal peptide in Escherichia coli BL21 (DE3)
In this research, Escherichia turner control wire coli BL21 (DE3) harboring an expression vector constructed with a rhamnose-inducible promoter and a pelB signal peptide was used as a host cell to produce MPT64 protein.The objective of this research was to figure out the optimum time of mpt64 gene expression through real-time monitoring of MPT64 pr
Process Optimization of Cold Metal Transfer Plug Welding of Aluminum AA6061-T6-to-Galvanized DP590 Steel Based on Orthogonal Experiment Method
In this paper, cold metal transfer (CMT) plug welding of aluminum AA6061-T6-to-galvanized DP590 steel is studied using AlSi-5 welding wire as filler material.The influence of wire feeding speed on welding quality is one of the research emphases.Firstly, an orthogonal experiment is designed to investigate the impact CONSOLE TABLES of wire feeding sp
When a Diuretic Causes Pulmonary Oedema
Background: Hydrochlorothiazide (HCTZ) is one of the most popular drugs for the treatment of hypertension and ASTRINGENT heart failure.Most of its side effects are harmless and predictable, but some studies report a few life-threatening reactions to this drug, one of the most dangerous being acute pulmonary oedema.Case Report: A 73-year-old woman w
Immunological Roles of Fibroblast-Like Synoviocyte Cells in Rheumatoid Arthritis
Introduction: Fibroblast-like synoviocytes (FLS), also known as synovial fibroblasts or type B synoviocytes, are the primary cells responsible for the structure of the synovial lining.They are crucial for the formation of a healthy, organized synovial lining.In rheumatic synovium affected by inflammation, the typical three-layered synovial lining t